What is a lotto combination? A number combination is a set of lottery numbers equal to the draw size (e.g. pick-5, pick-6) of a lotto to play for one draw panel on a lotto ticket. For example, in a lotto game with a 6/50 format, any set of six numbers from 1-50 is a number combination. 3-14-15-20-27-45 is one such combination. The winning set of numbers drawn in a lotto game is a number combination. A lotto wheel will give you many sets of combinations to buy, so your numbers overlap in order to give you a minimum win guarantee.